Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse. Diabetes 2014;63:1594–1604
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چکیده
Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse. Diabetes 2014;63:1594–1604 DOI: 10.2337/db14-er08 Tatiana L. Fonseca, Joao Pedro Werneck-De-Castro, Melany Castillo, Barbara M.L.C. Bocco, Gustavo W. Fernandes, Elizabeth A. McAninch, Daniele L. Ignacio, Caio C.S. Moises, Alexandre Ferreira, Balázs Gereben, and Antonio C. Bianco In the print version of the article listed above, the correct name of the author listed as Alexandre Ferreira is Alexander R. Ferreira.
منابع مشابه
Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse
Type 2 deiodinase (D2) converts the prohormone thyroxine (T4) to the metabolically active molecule 3,5,3'-triiodothyronine (T3), but its global inactivation unexpectedly lowers the respiratory exchange rate (respiratory quotient [RQ]) and decreases food intake. Here we used FloxD2 mice to generate systemically euthyroid fat-specific (FAT), astrocyte-specific (ASTRO), or skeletal-muscle-specific...
متن کاملThe FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration.
The active thyroid hormone 3,5,3' triiodothyronine (T3) is a major regulator of skeletal muscle function. The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (T4). Here we show that type 2 deiodinase (D2) is essential for normal mouse myogenesis and muscle regeneration. Indeed, D2-mediated increases in T3 were essential for the e...
متن کاملبررسی مقایسه‌ای اسیدهای چرب اشباع و ترانس و سیس در بافت چربی و سرم بیماران مبتلا به دیابت نوع 2 مراجعه کننده به انستیتو غدد داخلی و متابولیسم
Background & Aim: Diabetes is a heterogenous disease which results from complex reactions among heredity, nutrition and lifestyle. Some studies have shown that a high intake of saturated fatty acids(SFA) increases the risk of type 2 diabetes, while polyunsaturated fatty acids(PUFA) decrease diabetes incidence by increasing insulin affinity to the receptors. In this study, serum fatty acids ...
متن کاملType 1 deiodinase is stimulated by iodothyronines and involved in thyroid hormone metabolism in human somatomammotroph GX cells.
BACKGROUND Local 5'-deiOdination of l-thyroxine (T4) to the active thyroid hormone, 3,3',5-tri-iodothyronine (T3) via two deiodinase isoenzymes (D1 and D2) has an important role for various T3-dependent functions in the anterior pituitary. However, no evidence has been presented yet for thyroid hormone inactivation via the 5-deiodinase (D3) in anterior pituitary models. METHODS Using the huma...
متن کاملEvaluation of Thyroid Autoantibodies in Type 2 Diabetes
OBJECTIVE: Diabetes mellitus and thyroid disease are the two common endocrinopathies seen in adult population. Studies to evaluate thyroid disorders in patients with type 2 diabetes are lacking. The aim of this study was to compare prevalence of thyroid dysfunction and autoim-munity in type 2 diabetic patients with age and sex matched non-diabetic control group. MATERIAL AND METHODS: Among pat...
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عنوان ژورنال:
دوره 63 شماره
صفحات -
تاریخ انتشار 2014